Most Hated Couples

Lauren and Vaughn (ALIAS)
Sydney and Will (ALIAS)
Jess and Rory (Gilmore Girls)
Blair and Nate (Gossip Girl)
Joey and Rachel (FRIENDS)
Monica and Richard (FRIENDS)
Brooke and Lucas (One Tree Hill)
Ted and Robin (How I Met Your Mother)

I can't think of anymore right now, but I am sure that there is more.
I'll edit later

Where do I start ^^

Blair & Nate (Gossip Girl)
Blair & Carter (Gossip Girl)
Chuck & Vanessa (Gossip Girl)
Serena & Tripp (Gossip Girl)
Karen & Dan (One Tree Hill)
Brooke & Felix (One Tree Hill)
Lucas & Lindsay (One Tree Hill)
Keith & Jules (One Tree Hill)
Monica & Richard (FRIENDS)
Chandler & Cathy (FRIENDS)
Vaughn & Lauren (ALIAS)
Sydney & Will (ALIAS)
Ted & Robin (How I Met Your Mother)
Lorelai & Max (Gilmore Girls)
Seth & Anna (The O.C)
Marissa & Luke (The O.C)
Ryan & Lindsay (The O.C)
Ryan & Theresa (The O.C)
Summer & Zach (The O.C)
Angel & Nina (Angel)
Fred & Gunn (Angel)
Cordy & Groo (Angel)
Buffy & Spike (BTVS)
Alex & Willow (BTVS)
Buffy & Scott (BTVS)
Willow & Kennedy (BTVS)
Max & Tess (Roswell)
Izzie & Jesse (Roswell)
Liz & Sean (Roswell)
Piper & Dan (Charmed)
Piper & Greg (Charmed)
Phoebe & Leslie (Charmed)
Paige & Richard (Charmed)
Derek & Addison (Grey's Anatomy)
Derek & Rose (Grey's Anatomy)
Meredith & Finn (Grey's Anatomy)
Tru & Jensen (Tru Callling)
Dawson & Jen (Dawson's Creek)
Dawson & Gretchen (Dawson's Creek)
Booth & Cam (Bones)
Veronica & Duncan (Veronica Mars)
Veronica & Piz (Veronica Mars)
Logan & Parker (Veronica Mars)

I think that's it

Lucas and Lindsay (One Tree Hill)