Lucas and Peyton (One Tree Hill)
Chuck and Blair (Gossip Girl)
Juliet and Sawyer (LOST)
Jack and Kate (LOST)
Claire and Charlie (LOST)
Nathan and Haley (One Tree Hill)
Jim and Melinda (Ghost Whisperer)
Michael and Sara (Prison Break)
Tru and Jack (Tru Calling)
* I'm now adding:
Stefan and Elena (The Vampire Diaries)
Damon and Elena (The Vampire Diaries) even though it's not a real couple
- Spoiler:
even though they are in the book series
and Jeremy and Vicki (The Vampire Diaries)
Seth and Summer (The OC) (how could I forget them?
)